He's experiencing auto-inmune disease symptoms and we were told he is in critical condition. I've tried Gatorade and Ginger ale but he only drank a little. They did a blood test (this is literally 7 days later) and his ATL liver levels were off the charts at >2000. I feel so sad for you Camelia. He has all the symptoms Eveyone is describing. But today she isnt eating well, had a bout of diarrhoea and is very tired. Last month she had diarrhea and it lasted 7 days. She gets anxious and paces if I run into the grocery store even though my husband sits in the car with her. Hope all is well .my dog is 3,ive had him on Simparica trio for about 1.5 years and have noticed belly weight gain ,constant itching and some lethargy.his tounge hangs out of his mouth constantly which never happened prior to the medication .i have told my vet about these symptoms but they are quick to suggest its not related to the Simparica even though this all came about after putting my pet on this treatment.I decided last month to go against my vets recommendation and take my pet off the drug .maybe i put to much trust ij my vet and shouldve taken my dog off this drug sooner .better late then never .anyone suggest a tick and flea treatment less harmful for dogs ?? Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching . They were taking Simperica for flea/tick and Heartguard to prevent heart worms. He is 5 months old. This was the first time she was given this drug and will be the last. Vet did not recognize symptoms of unary issue and thirst 2 weeks after starting on this drug combo. I just gave him heartgard and nexgard about 2 weeks with no issues. I'll continue to watch her. and now i'm on an hour by hour let's see if she will perk up. After about a week, she started to improve. Tuesday morning she woke up with horrible diarrhea. He looked like he was having a seizure. I lost my girl 2 days after taking Simparica. They got him to eat a little the next morning and sent him home. He will be laying then start shaking all over..Has tremors every 5 minutes for 2 hours now. She is absolutely miserable and we're hoping she makes it. This will kill fleas and ticks. I dont want to have to put my dog down but hes suffering. I will never give another dose to him! We did abx, shampoos changed food. I will be changing clinics immediately. Later in the fall I noticed some leg tremors when she squatted. I am sure simparica caused a fatal seizure in my boxer. Plan to take him to see the vet tomorrow. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. I just wanted them gone and for him to feel better. Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. I should have kept with my gut feeling about any of these oral meds. Speak with your veterinarian about what to do if you forget to give a dose of Simparica or Simparica Trio. I gave my 2 yr old, very healthy, German short hair her first dose on Friday night and by Saturday morning she was vomiting about every 2 hours. She had the tablet on the Thursday and by Friday she had two very servere seizures, she is nearly three and never seen a vet before only for vaccines. She looked it up and said they were a ton of recalls and she admitted to me that that is what possibly killed him because it was on the recalls and theyd had mini dogs come in for the same issue. This is still going on weeks later. Vet says Simparica is not the reason for his condition, but he was totally fine prior to taking Simparica!! It definitely can cross blood brain barrier and cause other neurological issues so it makes sense it could do this too, but clearly they havent done enough research to understand how. Simparica, NexGard, Bravecto & Credelio may not increase the number of seizures, but the risk is real. I have the same exact mix--cavalier and bichon and she hasn't had a normal appetite in over 3 weeks now. He also had a blood test done and all was normal. Something I will never know what happened to herIf I knew this would kill her I would never had used it. Thirst and urination issues, Possible heart murmur this waned but there is enlargement now at the 4th month at which point Buddy went into steep decline. If it was due to the Simparica, then it would expected to be resolved within a day or two. What number do we call for FDA? Side effects are rare and may include: Vomiting Lethargy Diarrhea Loss of appetite Neurologic side effects have been seen after using medications in this class of drugs. By June 7th, she had a rash over most of her body, itching and biting herself to bloody raw spots. My 5 year old Bichon Frises, Ivy, was on NextGard for years. My other Lab after 5 days started having severe diaherria (black at first, now golden) and now throwing up too. No more of this junk for my pups! So new pup goes on garlic tabs-as he growing I'm upping the amount because I wanted him to be protected. After reading theses comments I started looking into SIMPARICA TRIO. The Trio product by Simparica is a three-in-one medication to control and prevent flea, tick, and heartworm. like she wants me to fix it. My family saw it , I did not . Very dissapointed with my vet for not informing me of the risk this has on my dog. Buddy 8 year old male Boxer formerly energetic and playful. I am giving her supplements to support her heart and nerves and she's a little better each day. Side effects are rare and may include: Neurologic side effects have been seen after using medications in this class of drugs. Its hard to say since he has previously been diagnosed with lymes. She said to watch for drainage. I threw him his ball and he actually was interested in it. It is like night and day compared to her regular personality or demeanor. I wish I would have came across this before I gave my healthy 9 month old puppy this medication two days ago. I gave this to my 2 rescue frenchies.. 2 days after 1 of them threw up..she didn't want to eat and started stumbling..leaning to the right, I thought vestibular but that is old dogs disease..I took her to the vet, did bloodwork that came back ok..she is on steroids and anti nausea meds..she is eating now..drinking alot and acts like she is deaf..she is only 6 yrs old. She uses drops 4 times a year on the top of the neck for fleas etc and told me to address the heart worm problem with the vet. Mine has tremors once in a while and now I know why! Simparica is good at killing contagious parasites that cause mange and scabies. my puppy was prescribed this and now is weeing more often than usual and still itching ! Now do you get the connection? Oh how I wish I had know the side effects of this medicine I would never haven given it to her.. the company that makes this poison should be sued. My vet recommended Simparica Trio for both my dogs (13 year old healthy Collie mix 7 lb chihuahua mix). He has been very healthy, and it does not seem to bother him, but it is becoming more noticeable recently. PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs), 6 Doses. What should I do? Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. have been seen after using medications in this class of drugs. It has been 5 days since she had the 3 seizures in 24 hours. For me, Simparica Trio has made parasite control effective and easyI just give her one chewable tablet each month. Advised I could call Simparica for reimbursement or to report side effects. We are now at about 45 days since last simparica and he is back to his old self. She has been taking Trifexis for years with no problem. Im still confused. She also started with ear infections. I realized he had no control over his body . I wanted to investigate a bit before dosing him. HELP!! He has trouble raising his leg to urinate. Nothing they can do for her she said. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. A few hours later, he began vomiting nonstop. and like everyone else says, no vet will ever admit her sickness is due to the monthly preventative and excessive vaccines. Today June 1,2022 she is still having neurological problems. Just a little nervous !! The vet did a nasal lavage under anesthesia and got a lot of mucus. I gave 2 of my older Labs a dose of Simparica on a Saturday. Was checking out before using . Other adverse reactions like lethargy, anorexia, itching, and increased thirst are possible but not very likely. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. If you havent already done so, please call the simparica trio phone number and report your dogs symptoms. This morning was the first morning he left water in his bowl. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. After reading all your entries, i'm thrilled i chose to take her off of it. All oral tick meds are a risk. Vet said "cant be Simparica because he had 9 days ago". Omg my girl goes threw incredible itching this has lead to us takeing her to the vet because she gets infected from scratching herself to death. So far, the cost of diagnostic tests are about $700. I just cross my fingers every day that she will get better after this is out of her system. I even told them about the Simparica which they dont respond to. Previously B was on Heartgard and Advantix worked well I guess we switch back. He isnt losing weight but really looks horrible. Or has it been too many doses ? Her Liver enzymes were also through the roof. and you expect people to give this to their beloved pets? My Lab mix has had 2 doses of this med. Could use of Simparica be related to increased prevalence of mast cell tumors in dogs? My French bulldog 2 years olds had a second attack in 3 days. All antiparasitics for dogs lower the seizure threshold. Kind of ooze. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. Well, let me tell you: THANK YOU ALL FROM THE BOTTOM OF MY HEART. Very small sample - many deformities, stillborn. He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. He also got that odd cough here and there that I read someone else mention. She is still in the vet since 3am. Thank you all so much for this thread and giving me hope. I wish every one the best. My Labradoodle had extreme diarrhea last night. Will never use again. org to have this poison recalled. Our new vet has recommended Simperica, but I wont be giving it to my Collie. Seriously I have had the worse luck. I called the maker of Simparica and filed an FDA case for my dog and told them all of the symptoms she was having from this medicine. How old was your pup? Im a new pet owner and this will sound ignorant Im sure but I had NO IDEA this is how flea meds works and completely trusted my vet who knows my dogs past sensitive history and I was given the drug not even in its package so I could read anything about it but in individual pills. Gave my 14 month old 88 lb. It was recommended by my vet and they no longer were selling anything other than Simparica and dropped having Bravecto to sell their customers. I am so worried about her! We were so upset - I vowed to never use oral flea treatment again. When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. Simparica chewable is a preventative that is better suited to healthy adult dogs living in areas where ticks are prevalent. Cooper.. 8 years old By chatting and providing personal info, you understand . The vet and company are in consultation. In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. In our case the damage was permanent. I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation . I bought chicken last night he ate some of that . Omg, this is beyond awful and makes me so worried. I am worried! The prescription-only chewable tablet is given once a month to dogs and puppies eight weeks and older. Oh Lord, back to finding another vet. That was when I lived in Fort Lauderdale. Has anyone recently started simpatico trio on their fur baby and noticed any kidney problems? well my lola went into labor xmas day. Consulting vet and will not give Simparica ever again. The vet suggested this medication for my 9+ yr old English Bulldog. I'm so sorry. Thanks! I am interested in the petition and the company's response. Thank you! I have a happy healthy 14 yr old female bull terrier. Revolution has been around decades with less incidents of animal reactions. Nobody knows what causes it or makes one dog recover and another not. Just gave 3yr old OES first dose yesterday (her half sister got one too) and today she has uncontrolled urination. I looked up side effects for this drug and was horrified to find that the flea med can cause tremors seizures and worse. He did blood work and found that the phosphorus levels in her blood were way to low and that was causing the neurogical problems and it was most likely from Simparica Trio. For those who lost their dear companions from this medicine my heart goes out to you all. Is there hope? I had a trainer come in the day of, and he was with me the all day, NOTHING a happened for him to be in pain! Each medication combats different pests. I don't know if the lump came from it or something else. She is still eating but she is drinking more water. I won't be letting this go and I'll be actively pursuing recourse from the manufacturer and vet in any way I can. It could be something else that had caused her all the pain she went through but I surely will not give my puppy Simparica anymore and I hope she is alright. I would find another vet for a second opinion. He seems sometimes anxious and is sensitive to noise outside. Today March 20 (8 week old) I get a message saying the puppy ate one of these pills that was for the bigger dog she already owned. It is Easter Sunday and he still has diarrhea and drinking a crazy amount of water. Does anybody know how long this will last? Instead it has become a world of greed. They could either keep her there for observation or I could take her home to observe her. Called his vet and they gave no information. Im trying to understand how. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. Do you have a homeopathic vet in your area? It's been the worst 2 months. It causes paralysis that leads to death of hookworms and roundworms. Gave my dogs simparica and they both have lost their appetite! Called vet and was advised chicken and rice by tech - vet did not come to the phone even tho I asked to speak to her twice. Some pets fare better with topical solutions instead of chewables. What are the side effects of Simparica trio for dogs? this link is to an external site that may or may not meet accessibility guidelines. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. My dog has had a previous back leg surgery. I will NEVER give this drug to my dogs! He eats and drinks fine but looks like we havent fed him in days. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. Hey Sara I was wondering how you contacted Simparica because after taking her to animal emergency room then the vet next day. Does anyone know of anything we can give her to help get this out of her system? They may not be ready to beat you in a game of chess, but these brainy dogs are easy to train and generally eager to please you. I would notice he gets super tired walking and would go limp in my arms. He has been low energy since. I went to banfield hospital and they prescribed this medication for my dog and had thrown up non stop since he was given the pill and wouldnt eat anything and he passed away 10 days later (yesterday). Thank you for this. Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs. I gave this to my 8 yr old chihuahua and a couple days later he started having seizures. I will never give him this drug again. she has shaking off and on . Tell your veterinarian if your dog has a history of seizures or other neurologic disease. We nurses him back into a happy healthy puppy and now this. now seizures daily on all sorts of meds for it and the cost with medications to try and control seizures and vet visits and mainly seeing my once healthy playful full of life pups having seizures daily even in her sleep breaks my damn heart !!!!!!!!!!!!!! All is good! If she recovers, cause is the Simparica. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). I just gave my Matty her first dose. 4.3 4.3 out of 5 stars (34,534) $39.98 $ 39. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. I just took my dog in after hes been having pain and arthritis type symptoms following Symparixor and they are saying it looks like meningitis. Im convinced the medicine caused this and now she cant walk. Lone Star, deer, and American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs. I gave this to my #3. The product can be purchased directly from your vet, from your vet's online pharmacy, or through an external online pharmacy with a valid prescription. But today, after he ate dinner and drank water, it all came back up. It is better but not gone. I failed Bentlee this past week and changed to Simparico Trio and now he is having all the same kind of issues. She had some good days and we were hopeful but ultimately, she steadily declined. He is otherwise normal and healthy. . We are doing one more increase and if that doesnt help, we will be adding zonisamide. Simparica and Simparica Trio are available by prescription only. She hasnt eaten in 3 days and is unable to go up 2 simple steps. (toy aussie & corgi). My Irish setter is weak on her left side, left side of her face is drooping and she now carries her head with a tilt to the left. Your veterinarian may recommend a heartworm test if you are using Simparica Trio. Has there been any improvement if so how long after did it take ? Tick titer came back a light positive which lab said was specifically false due to the recent lyme x2 booster i was scared in to giving. He walked outside peed then tried to come back in the house but his legs gave out . My 2 1/2 mini goldendoodle has been on Simparica 10 days now. Within 24 hours, he would not leave my bedroom, slept all day, no appetite. I will be speaking to vet to switch to something else. So your dog got better? Today really soft stool (not diarrhea but close). And im so mad that my vet didn't inform me of the side effects and im so mad I didn't research it myself. He seemed to get a little better over the next week until he woke at 5am vomiting and having diarrhea and very lethargic. It seems to be clearing up with Rx eye drops. You keep your dog cages? It is also labeled for the treatment and prevention of the Gulf Coast tick, American dog tick, black-legged tick, lone star tick, and brown dog tick. Yes, she was still having seizures! Our two year old dog took the same thing and thank god she has no symptoms. He had been on it for 4-5 months . Many people have reported this as only temporary. She seems more anxious now and really attached to hubby. It comes in a pack of six or 12, but veterinarians typically sell individual doses for growing puppies. My dog was super sick the first months of his life. Has anyones dog stopped having seizures when the medication wore off or is this going to be a permanent issue possibly getting worse? I don't give him much treat eather. Hopefully there are many other dogs that are unaffected, and just aren't written about here. He has been drinking more water then usual. Back to the vet and I hope they credit my money. Yep days ago started vomiting and having seizures. She has been very unpredictable and snapping at people but this is improving. We gave our one year old Simparica tonight and he started having trimmers that lasted on and off for about 30 minutes. The vet just gave our 16lb shorkie this on Tuesday and he still has the tremors really bad and very lethargic, Im very worried and concerned. Once she is completely healed I am putting her back on those. I feel its from the Simperica trio and will not give it to them ever again. But I noticed that I had to "wake him' several times in only 2 minutes time, but he wasn't sleeping, his eyes were open and I saw them rolling in the back of his head! Thank you. Just wondering? By the evening she lost the use of her hind legs. I immediately filed a case number with Zoetis and informed my Vet as well as current Vet hospital he is being held at. Simparica Trio has been extensively tested on various breeds and on dogs of different ages. Needless, to say I will not be giving them the simparica trio again. Those with Diarrhea symptom, did it look like mucus in their pets stool? My poor baby! Im switching back to the protection he used before Simparica Trio. Be aware! just gave my one year old dauchund her first dose of simparica My vet didnt tell me, We gave our Yorkie this and she went into seizures later in the daywhat if any thing can be done. If this is a long term issue, I doubt they would be willing to cover all visits in the future. However, besides being nervous over the diarrhea, I am petrified about all of these people talking about seizures. My 6 year old Chihuahua has been on simparica trio for 4 days . Things like: tremors decreased conscious proprioception ataxia reduced or absent menace, and or seizures Simparica is not recommended in lactating, pregnant females, or dogs used for breeding. I sure hope we don't have ongoing problems. What do I do? The next morning, she had uncontrollable tremors and could not walk without falling down. I will update once we have results from diagnostics. I gave my 10 year old Bull Terrier a dose of Simparico Trio Thursday December 3. I will have to keep an eye out on her. I shall be looking for a natural product from now on, k and g pet supplies on amazon do a good mange spray so hopefully that will be all they need from now on. They gave him IV glucose to raise his Potassium level. but wasnt allowed in with him. We took him to a emergency Vet Hospital that pin pointed Simparica Trio as the main facture that triggered his controlled seizure episodes in having constant all day tremors & seizures hurting him to the point of making the decision to put him down or have him continue with the pain until it killed him. And yeah he ate today 4 chicken breast and appeared to want it even better. Then he starts scratching and as time goes on he seemed like something was wrong. Now that Ive read all these comments I think he has developed these issues because of this trio medication. For the first time in 12 years my dog has 6-7 large kidney stones which will require surgery. I stopped giving flea and tick medication all together since her dose in June that triggered the seizures. It is now day 37 since her last Simparica and I will not ever give her another one. Im going to keep a close watch on him over the next few days. Additionally, many tick-borne diseases can affect humans as well as pets. I would not recommend giving Simparica to your pets!!!!! We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. These oral meds into a happy healthy puppy and now she cant.... Good days and is sensitive to noise outside store even though my husband in! Expect people to give this drug combo morning and sent him home watch on him over next. 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These people talking about seizures havent fed him in days 5 year old male formerly. Sickness is due to the Simparica Trio for both my dogs ( 13 year old tonight... Be letting this go and i will have to keep a close watch on over.
