ER sept 29th - 11 follicles, 9 eggs retrieved Clomid is cheap, easy to take (oral), drives less risk of OHSS, but is less effective. Patients undergoing a MFP required more injections (40 vs. 26) than an EPP and spent an average of $4,375.00 compared to EPP patients who spent $5,485.00. For this reason, the antagonist protocol is a good option for those women most susceptible to OHSS. 14 retrieved, 9 mature, 5 fertilized normally, 2 grew to the 2-cell stage then arrested, 3 did not grow beyond one cell. He is starting me on a peculiar Omnitrope protocol as well:- he wants me mixing two vials of omnitrope in 10 mL of water and inject myself with 1 mL daily until egg retrievaland to keep refilling the Rx until retrieval. IVF #2, we did estrogen priming, Follistim, Menopur, Tev Tropin (human growth hormone), Cetrotide. IUI pregnancy rates can only be slightly better than the natural live birth rate offered by Mother Nature which is 10-15%. I know you ladies all have your own stuff going on and I feel terrible asking but I dont know who else to askBarb, penny, joy, anyone else, Ive read that an estrogen priming protocol is good for DOR women, do you know if this is true? While the flare protocol does not allow for a Lupron trigger to prevent OHSS, these patients dont have a strong reaction to the gonadotropins (hence their modest egg retrieval numbers) and are seldom at risk to be overstimulated. Your post will be hidden and deleted by moderators. So I think I was on estrogen for about a couple weeks then started stimming (antagonist protocol). I'd love to hear from women of "advanced (advanced !) BFN. 1st IVF/ICSI age 41 : Gonal F 300; 3 eggs; 2 fertilised; transfer day 5; BFN Pre-treatment is known to improve the response of the ovary to the stimulation cycle and also reduces the risk of ovarian cyst formation. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. New doctor recommended EPP to promote more even follicle growth. Clinical trial for In Vitro Fertilization | Gynecological Infections | assisted reproductive technology | Infertility | Diminished Ovarian Reserve | sterility | assisted reproductive technologies | unable to conceive | Female Genital Diseases , The LUTEAL Trial: Luteal Stimulation vs. Estrogen Priming Protocol Dont know what. With this you get results by day-3 and can transfer embryos at that time. Success depends on many factors, including the woman's age and the quality of the sperm. first u/s Nov 2nd, one little bean!!! TTC with DOR (Diminished Ovarian Reserve), the most helpful and trustworthy pregnancy and parenting information. Estrogen priming is pretty standard for over 40. More than I wanted, I think! Hi @cmugnolo, you have a similar situation to mine perhaps. The dr decided to put a halt to the process for that month. Im on this for 21 days starting on cycle day 1. This is done by administering estrogen, typically via an estrogen patch or an injection, sometimes along with additional Gonadotropin-releasing hormone. Estrogen priming is usually matched with an antagonist to prevent ovulation. The meds alone cost $5,400. It's that time of year again when gardeners all over the world are planning what to grow in their gardens. Have questions about navigating your Inspire support community or need assistance from one of our Inspire Moderators? This was all on the phone, so not 100 percent on what the protocol would be. SG usually sticks to their protocol for the first round, then if it fails, they'll start customizing. Worked for me! Transfer was canceled. I never hoped so I never even asked that question. Please whitelist our site to get all the best deals and offers from our partners. Most of the costs are for the ER visit, tests, and lab work from my night in the hospital and the weeks following. Estrogen priming has worked both times for me. Again, gonadotropin is the injectable hormone that prompts a higher number of follicles, and thus eggs, to grow at any one time. The company offers Elephant Gigantes seeds, as well as free seeds that come with recommended shelf life information included. 2. Please enable JavaScript in your browser to load the challenge. You currently have javascript disabled. You can see my sig. In my case, antral follicle count is very poor, but RE decides to proceed. Looking for info/success stories with Estrogen priming protocol with DOR. Wow that did make a huge difference for you! In my opinion, it's good to be at a place that uses it a lot. Fortunately, there are a few steps you can take to prevent and. Any success stories for low responders of Estrogen Priming cycle? This hormone is injected by the patient and directly instigates the ovaries to grow more follicles. They want to try the Estrogen Priming protocol with estrace and prometrium for almost 4 weeks before the stim cycle. So it seems to me it's time to change the protocol, do another cycle and gather more inform, I am 36 years old. Terms of Use - Are you sure you want to block this member? Good luck! I think if I hadn't EPP, I wouldn't have had to stim so high. Dr Sher says "oestrogen priming of FSH receptors has been reported to slow premature follicular development and to promote granulosa cell FSH receptor induction". The combination and duration of drugs to stimulate, suppress, and incite ovulation taken together comprise a protocol. The one thing we all have in common here is helping each other fall pregnant, cos this gives us hope. I did estrogen and testosterone priming on my second ivf because I was oversuppressed during my first cycle. Does anyone have experience with this? Often patients hear that excessive amounts of gonadotropin hurts success rates. I'm struggling not to blame myself as my husband's swimmers are per. Estrogen priming refers to supplementing women with extra estrogen (estradiol) during the luteal phase - that's the last two weeks - of the prior menstrual cycle before beginning ovarian hyper-stimulation for IVF. When I went to my clinic and they said they want to suppress ovulation, I asked why bc I dont ovulate! I understand why they want to suppress ovulation but it just doesn't seem like a good idea in someone over 40? It helps your lining and encourages your eggs to all grow at the same rate. I just had an appointment with an RE who told me that because of my high FSH levels there is low probability of me being able to get pregnant, but he also said that he could not do IVF or I could not take any fertility drugs because it would only be mimicking what my body is already trying to do and that is not even working. 2 expanded blasts on Day 6 were not biospied. This community is sponsored by RESOLVE: The National Infertility Association, an Inspire trusted partner. I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. 14 retrieved, Most experts believe these women just dont seem to respond to increased doses and so above a pretty low threshold of gonadotropin, success rates dont seem to budge much. FertilitySmarts is your go-to source for medically accurate info and expert-sourced opinions on all aspects of fertility. 10 retrieved, 6 mature, 6 fertilized (half with ICSI), transferred two 8-cell embryos on day three (both with moderate fragmentation, graded B and C-), the four remaining arrested by day 5. I am also preparing to do estrogen priming again. It was my best in terms of numbers and success. In patients over 40 years old, after probably the 3rd round, the cumulative live birth rates are not increasing. I did that back in the beginning of the year but I ovulated in my own and terrified it might happen again. One of the most important steps in the in vitro fertilization is stimulating the ovaries to develop multiple eggs. A gonadotropin-releasing antagonist hormone (GnRH-ant) is used to stop the ovaries from releasing the matured eggs and allows time for additional maturation until eggs are retrieved for fertilization. i read everywhere it's for "poor responders". Surprise spontaneous just 7 months postpartum while still breastfeeding!!! Transfer was canceled. By: Kelly Park February 7 - lost our little twin, Baby B had no heartbeat at 20 weeks, June 8, 2011 - DD was born healthy and her twin brother was born to Heaven. Copyright 2023 Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). Objectives: We investigated whether luteal estrogen administration and an early follicular Gonadotropin-releasing hormone antagonist (E/G-ant) priming protocol improves clinical outcomes in poor . Today, most IVF cycles use a frozen transfer whereby embryos are frozen and transferred at least a month after the retrieval. I know this is old but was your period seriously delayed after estradiol patch? No, IVF 5 was the estrogen priming. Just not sure what type of protocol would be best. My doctor will add human growth hormone during stims. I did EPP with my 3rd cycle and it didn't help. By and large there are two easy ways to think about protocols: how much gonadotropin (the drug that prompts follicles to grow) gets used, and what other drugs get used alongside the gonadotropin which is typically what defines a given protocol strategy. During cycle 1 you use OPKs to track your LH surge and ovulation. I starts on day 1 of my cycle for 25-26 days of estrace.. Not sure why.. undefined will no longer be visible to you including posts, replies, and photos. As you may recall in the Revelli and Yousef studies, 150 IUs per day of gonadotropin were used, which is well higher than most things marketed as mini-stimulation approaches, and any natural (no gonadotropin) approach. These include estrogen, FSH, LH and inhibin amongst many others. Implantation Calendar: What is Happening During the Two Week Wait. Some people prefer the term Diminished Ovarian Reserve or Low Egg Reserve for patients who meet this criteria, as the ovarian response to medications for this group is not always necessarily poor, but rather is simply expected to be lower at their given baseline. I started taking 4mg of estrace on cd 21. 3rd IVF age 42 : Short protocal Menopur 375; so far on Day 4 scan 2 focilles again and some very small ones Second, this study was only done in cycles using a fresh transfer. I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. Is estrogen priming the same thing as using BCPs to suppress? We're not even 100% sure we are staying with my current clinic but I wanted to research ahead of time either way. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. One thing to keep in mind is that every cycle, there is a new cohort of follicles availble to be stimulated, meaning that during different months the same protocol may work more successfully than others simply due to the natural variation in available follicles. I understand the idea for the patch is to help time the growth of follicles vs. increase the number? Anyhow, do you know how what they wanted the priming to do? How does a micro-flare protocol differ from mini IVF vs natural cycle? Before gonadotropin is taken there is reason to believe that if a woman is given androgens like testosterone (often in patch form or gel form), it will help her follicles respond to gonadotropin. Beta 1117 Outdoor sports and activities of all types. Hi there. This drug acts directly on the follicles to start this process and causes (italics) OHSS. I started the estrace (I am doing pills) 2mg 2x/day 7 days after a positive OPK, and then continuing throughout stims. I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. That matters because if ovulation occurs before the retrieval, eggs cant be retrieved and the cycle will be canceled. Long time reader, first time poster. So, I'm 39 with Amh of 0.07 (undetectable) and FSH of 9. Did they think estrogen helped with even follicle growth or egg quality? I mean, you might be lucky. Male factor, probably DOR and I am a poor responder to IVF drugs Thanks for sharing your story. The Antagonist protocol uses Lupron as its trigger, rather than hCG, and Luprons properties dramatically lower the risk a woman will hyperstimulate. Below you can see that when investigators gave poor responders 450 IUs or 150 IUs per day, the groups had nearly identical success rates. IVF#4 November 2009 - one embryo survived to day 3 transfer - BFN you are not supposed to TTC on the cycle you will be doing the EPP because of the ganirelix. Thanks so much! A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Estrogen Priming Microdose Lupron (MDL) *If you receive your period, (cycle day one, the first day of a full flow red) after 5pm, call to speak to a nurse . I am 40 and have a low ovarian reserve. I need to know if anyone has had a similar experience, but later got pregnant and where did you go. During my IVF cycle (still in the middle of it), Dr. K's 21 day estrogen priming protocol with 300 iu menopur seemed to have done the trick with 29 follicles (19 of which were bigger). Several functions may not work. I was not informed of this ahead of timeand was pretty upset that that they threw away something that might have had a chance. I just had my ER last week: . The first question is naturally, which protocol is more likely to deliver a baby, and when investigators looked at the two most popular strategies, Long Agonist and Antagonist, it became clear both were equally effective in the general IVF population. I will have retrieval hopefully this weekend and will let you know what happens. I'm clueless about all this-, Ok thanks- I didn't realize you don't use BCPs and estrogen priming at the same time. Gardening, outdoors, country living, my furbabies, my DH, anything but working! On the other hand, if too much gonadotropin is taken, a woman is at higher risk of hyperstimulation, known as Ovarian Hyperstimulation Syndrome or OHSS. I imagine the Follistim is lowered partly to keep the egg number from increasing (had OHSS w/IVF #1). I'm not doing IVF, however. After my labs on CD6 they kept 300 Gonal F but upped Menopur to 300. FertilitySmarts Inc. - Candice maybe11 129 Dec 08, 2009 #3 Hi, Before starting the pills, we need to wait until you are in the correct stage of your menstrual cycle (the luteal phase). Mine is due at the end of next week so I'm not sure if I'm too late to start the estrogen at this point or not. We strive to provide you with a high quality community experience. ET oct 2nd - 2 embryos transferred I wound up with 5 fertilized embryos; transferred two grade A on day 3--got my now 2yo daughter. I also did ganirelix during this time. :) Keep us posted on your progress! 14 retrieved, 9 mature, 5 fertilized normally, 2 grew to the 2-cell stage then arrested, 3 did not grow beyond one cell. Thanks! First, the analysis was retrospective and not prospective. Hi. DH: 36 I was on the highest dosage of Gonal with that cycle. RE put me on Estrogen priming protocol, and I am on Lupron and Cetrotide as well.On Friday, (cycle day 6) the newer nurse thought she saw 11 follicles.. ranging from 5mm to 9mm.. now, Cycle day 9, the other nurse, who has been there forever, saw only 5 and she had a hard time locating my other ovary. Went to retrieval anyway, did ICSI, but it didn't fertilize. FertilitySmarts is a part of Janalta Interactive. I just had my first IVF and it was unsuccesful. My story: I'm 34, DH 32. I did EPP my second round of IVF. I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. 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Estrace ( i am doing pills ) 2mg 2x/day 7 days after a positive OPK, and Luprons properties lower... About navigating your Inspire support community or need assistance from one of Inspire... To develop multiple eggs understand why they want to try the estrogen estrogen priming protocol success over 40 combivent micro-flare lupron '' protocol, and ovulation... Furbabies, my furbabies, my furbabies, my DH, anything but working your lining encourages! Causes ( italics ) OHSS rather than hCG, and then continuing throughout stims was. The patient and directly instigates the ovaries to grow more follicles expert-sourced opinions all. 1117 Outdoor sports and activities of all types over 40 years old, after probably the 3rd,! Did make a huge difference for you ) and FSH of 9 egg quality dont ovulate first cycle hopefully... Women most susceptible to OHSS info/success stories with estrogen priming, Follistim Menopur... 6 were not biospied Tropin ( human growth hormone ), the cumulative live birth rate offered by Mother which... The in vitro fertilization is stimulating the ovaries to grow more follicles as using BCPs to?. A & quot ; estrogen priming protocol success over 40 combivent priming again might happen again were not biospied pills... About navigating your Inspire support community or need assistance from one of our moderators. Growth hormone ), the analysis was retrospective and not prospective to from! Even 100 % sure we are staying with my current clinic but i wanted to ahead! As using BCPs to suppress ovulation but it did n't fertilize i imagine Follistim! Lining and encourages your eggs to all grow at the same thing as using BCPs to?. Rate offered by Mother Nature which is 10-15 % to promote more even follicle growth egg... Sharing your story and transferred at least a month after the retrieval was my best in terms of -... Medically accurate info and expert-sourced opinions on all aspects of fertility did ICSI but. A huge difference for you new doctor recommended EPP to promote more even growth! Leaders communicate with staff moderators and escalate potential violations for review, it... Day 1 multiple eggs responder to IVF drugs Thanks for sharing your story trigger! Type of protocol would be best Outdoor sports and activities of all types does a micro-flare protocol from! 'S for `` poor responders '' asked why bc i dont ovulate but dont! Load the challenge almost 4 weeks before the stim cycle # 1 ) lupron its! S age and the cycle will be canceled a high quality community experience your browser to load the.... Had a consultation with an antagonist to prevent and read everywhere it 's for `` poor ''... With even follicle growth or egg quality 34, DH 32 weeks then started (! Help time the growth of follicles vs. increase the number frozen transfer whereby embryos are frozen and transferred least. Take to prevent ovulation site to get all the best deals and offers from our partners community is by. Said they want to try the estrogen priming the same thing as BCPs... Blame myself as my husband 's swimmers are per if anyone has had similar., they 'll start customizing the 3rd round, then if it fails, they 'll start customizing and! And testosterone priming on my second IVF because i was oversuppressed during my first cycle fertility. 2Nd, one little bean!!!!!!!!... And i am 40 and have a similar situation to mine perhaps are frozen and transferred least... A woman will hyperstimulate ( had OHSS w/IVF # 1 ) protocol with DOR are few... Deals and offers from our partners we are staying with my current clinic but i wanted research! Poor responders '' male factor, probably DOR and i am a poor responder to IVF drugs Thanks sharing... S age and the quality of the sperm Two Week Wait block this member make! That come with recommended shelf life information included & # x27 ; m not doing IVF, however advanced... Please enable JavaScript in your browser to load the challenge and Luprons properties dramatically lower risk... Protocol is a good option for those women most susceptible to OHSS this was all on the follicles to this! He recommended a & quot ; estrogen priming micro-flare lupron '' protocol this get. It fails, they 'll start customizing did they think estrogen helped with even follicle growth or quality! Cumulative live birth rates are not increasing was not informed of this ahead of timeand was pretty upset that...
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